• Jacketed Models: Available for processes requiring heating or cooling.
• Vacuum/Gravity Charging: Optional feature for precise material charging.
• Mechanical Seals: Optional seals for enhanced containment and product integrity.
• Binder Spraying Systems: Optional systems for precise binder application.
• CIP/WIP/SIP Systems: Optional Clean-in-Place (CIP) or Wash-in-Place (WIP) systems for easy cleaning and sanitization.
• Vacuum Drying: Optional feature for drying under vacuum conditions.
• ATEX Compliance: Available for installations requiring compliance with ATEX directives for hazardous environments.
• Capacity Customization: Tailored capacities based on specific production needs.
• Additional Customization: Further customization options available upon request to meet unique process requirements.

• In-house pressure tested up to 2 Bar for safety assurance during operation.
• ATEX Compliance for installations in potentially explosive atmospheres.
• Emergency Stop Button and Overload Protection for operator safety.

1. Pharmaceutical Manufacturing:

Wet Granulation: High-shear mixer granulators are extensively used in pharmaceutical manufacturing for wet granulation processes. They facilitate the uniform mixing of active pharmaceutical ingredients (APIs), excipients, and binders to form granules suitable for tablet or capsule production.

Example: In the production of tablets, a high shear mixer granulator is employed to blend APIs, binders, and other additives into a homogenous mixture, which is then granulated to achieve the desired particle size distribution before compression into tablets.

2. Cosmetics and Personal Care Products:

Cosmetic Manufacturing: High shear mixer granulators are employed in the production of cosmetics and personal care products for mixing powders, emulsifying creams, and dispersing pigments.

Example: In the formulation of skincare creams, a high shear mixer granulator is utilized to blend oils, water, emulsifiers, and active ingredients to create a stable emulsion with desired consistency and performance attributes.

3. Nutraceuticals and Dietary Supplements:

Nutraceutical Industry: High shear mixer granulators are utilized in the nutraceutical sector for blending vitamins, minerals, botanical extracts, and other nutritional ingredients to produce tablets, capsules, or powdered supplements.

Example: In the manufacturing of multivitamin tablets, a high shear mixer granulator is used to mix various vitamins, minerals, and excipients into a homogenous blend, which is then granulated and compressed into tablets for convenient consumption.

1. Mixing Process:

• The mixing process in a high shear mixer granulator begins with the loading of dry powders, including active pharmaceutical ingredients (APIs), excipients, and binders, into the mixing bowl.
• The mixing bowl rotates, ensuring even distribution of the powders across the mixing chamber.
• Simultaneously, an impeller located at the bottom of the mixing bowl rotates at high speed, creating a downward flow of powders and generating intense turbulence within the mixture.
• The impeller's high shear force breaks down agglomerates and promotes the intermingling of individual particles, facilitating thorough blending.
• Optionally, a chopper mechanism may be employed to further disrupt large particles and ensure uniform dispersion throughout the mixture.
• The result is a homogenous blend of powders with consistent particle size distribution and uniform distribution of active ingredients and excipients.

2. Granulation Process:

• After the mixing phase, the granulation process begins by introducing a liquid binder solution or suspension into the mixing bowl.
• The binder solution is sprayed onto the rotating powder bed through a spray nozzle, coating the particles and initiating the granulation process.
• The liquid binder promotes particle adhesion and cohesion, forming small granules or agglomerates.
• The impeller's continued agitation ensures thorough distribution of the binder throughout the powder mass, facilitating the formation of uniform granules.
• The size and density of the granules can be controlled by adjusting parameters such as impeller speed, binder flow rate, and mixing time.
• Once the desired granule size and consistency are achieved, the wet granules are discharged from the mixing bowl through a side discharge valve for further processing or drying.

Overall, the high shear mixer granulator combines intense mixing with granulation to produce uniform granules with precise control over particle size and distribution. This process is vital in pharmaceutical manufacturing for the production of high-quality tablets and other solid dosage forms.

1. Superior Performance:

Our high shear mixer granulator delivers unmatched performance, ensuring precise mixing and granulation for consistent, high-quality pharmaceutical products.

2. Versatility:

Designed to handle a wide range of applications, our granulator offers versatility in pharmaceutical manufacturing processes, enhancing efficiency and productivity.

3. Quality Construction:

Constructed with high-grade stainless steel, our granulator is durable, corrosion-resistant, and compliant with pharmaceutical hygiene standards, ensuring long-term reliability.

4. Precise Control:

Equipped with advanced control systems, our granulator enables precise process control, ensuring consistent granule quality batch after batch.

5. Ease of Operation:

With intuitive controls and streamlined maintenance procedures, our granulator is easy to operate and maintain, minimizing downtime and maximizing production uptime.

Choose our high shear mixer granulator for superior performance, versatility, quality construction, precise control, and ease of operation. Experience excellence in pharmaceutical manufacturing with our innovative equipment solution.